LEONARDO ÁLVAREZ/33.4489°S 70.6693°W

Designing biology & the machines that understand it.

Fifteen years of computational biology; two companies built around the same instinct. Form follows function. The most exciting work lies where complexity emerges.

§ 01 · Now
04 · 2026

I build things at the intersection of biology, computation, and people. Lately the work has drifted from one kind of complexity to another. From predicting the structure of proteins to predicting the structure of organizations.

LEONARDO ÁLVAREZ
Santiago · 2024Self portrait
RoleFounder · CEO, Chask
BoardFounder, Protera   (2015 →)
Platformmadi™ · protein design
CitiesSantiago · San Francisco · Paris
Backed bySofinnova · SOSV · IndieBio
Trained inBiotechnology engineering · self-taught AI
Status● shipping
§ 02 · Ventures
02 active threads
Active build / EST 2024Shipping
Chask.
Shipping·Back office, reimagined
RoleFounder · CEO

An AI platform for the back office. Built on the thesis that LLMs need frameworks to guide them, contain them, and make them operate reliably. Not another chatbot wrapper.

Stageearly / bootstrap
Team7 / SCL
Decade in motion / EST 2015
Protera
Protein engineering·madi™ platform
SeatBoard · Founder

AI-driven protein engineering. madi™, a deep-learning platform, designs functional proteins for food, agriculture, and health. A decade-long arc; platform in production with Fortune-500 partners.

Raised$20M+
PartnersF500 / 4 programs
BiotechDeep learningSCL · SFO · Paris
Open thread
§ 03 · Side quests
Complexity · Beauty · Automation
Quest · 01Complexity

Complexity as universal law.

I keep returning to systems that resist a single explanation: biology, beauty, entropy. Something hidden ties them together. From how the first proteins found their functions, to why we feel beauty almost as second nature.

Quest · 02Beauty

Beauty and scale.

The universe is magnificent. Its scale unfathomable. That we can capture a piece of it, see it with our own eyes, and sit with the beauty of it: still incredible to me.

Small Magellanic Cloud
Small Magellanic Cloud01h 02m 36s · −72° 04′2023 · Atacama, CL
Quest · 03Automation

Automation as a game.

I'm a longtime RTS player. StarCraft, mostly: Master league, 250 APM at my peak. Ever since, I've seen automation and optimization as a real-life game. With Claude Code and the new wave of AI tools, the same instinct runs deeper than ever. Humans aren't meant for repeat. We crave creativity and complexity, and that's the engine behind every automation worth building.

§ 04 · Research
4 preprints · 3 patents

Selected research

Full archive →
§ 05 · Articles
1 on Medium
§ 06 · Press
8 appearances